ClinvarVcvStatement¶

Draft

This data class is at a draft maturity level and may change significantly in future releases.

A ClinVar VCV (variant classification variant) statement. Represents an aggregate classification for a variant across all submissions sharing the same proposition type. VCV statements contain evidence lines that group contributing SCV submissions by review status priority tier (practice guideline, expert panel, criteria provided, no criteria provided). VCV statements use the same 13 proposition types as SCV statements. Evidence lines at the VCV level contain nested sub-statements at the classification layer, each carrying the same proposition type as the parent but scoped to a specific priority tier. The innermost layer references individual SCV submissions as evidence items.

JSON Schema: ClinvarVcvStatement

Some ClinvarVcvStatement attributes are inherited from Statement, ClinvarAggregateStatementProperties.

Information Model¶

Field	Type	Limits	Description
`id`	`string`	0..1	The 'logical' identifier of the Entity in the system of record, e.g. a UUID. This 'id' is unique within a given system, but may or may not be globally unique outside the system. It is used within a system to reference an object from another.
`type`	`string`	0..1	MUST be "Statement".
`name`	`string`	0..1	A primary name for the entity.
`description`	`string`	0..1	A free-text description of the Entity.
`aliases`	`string`[] (unordered)	0..m	Alternative name(s) for the Entity.
`extensions`	`ExtensionClinvarReviewStatus`[] (unordered)	0..m	Aggregate-level extensions including the overall review status.
`specifiedBy`	`Method` \| `iriReference`	0..1	A specification that describes all or part of the process that led to creation of the Information Entity
`contributions`	`Contribution`[] (ordered)	0..m	Specific actions taken by an Agent toward the creation, modification, validation, or deprecation of an Information Entity.
`reportedIn`	`Document` \| `iriReference`[] (unordered)	0..m	A document in which the the Information Entity is reported.
`proposition`	ClinvarProposition \| `iriReference`	0..1	The aggregate proposition assessed by this VCV or RCV statement. Uses the same proposition types as SCV statements. The proposition at the aggregate level represents the consensus or highest-priority classification across contributing submissions.
`direction`	`string`	0..1	A term indicating whether the Statement supports, disputes, or remains neutral w.r.t. the validity of the Proposition it evaluates.
`strength`	`MappableConcept` \| `iriReference`	0..1	A term used to report the strength of a Proposition's assessment in the direction indicated (i.e. how strongly supported or disputed the Proposition is believed to be). Implementers may choose to frame a strength assessment in terms of how confident an agent is that the Proposition is true or false, or in terms of the strength of all evidence they believe supports or disputes it.
`quality`	`MappableConcept` \| `iriReference` (draft)	0..1	A term used to report the quality of the assessment of a Proposition taking into consideration the reliability of the method, the contributor's self-reporting of the rigor of the evaluation, and the overall robustness of the supporting or disputing evidence. This is useful when there is a consistent policy and authority that manages and a governing framework for evaluating the quality of evidence. Also known as trust rating, review status or ranking.
`score`	`number` (draft)	0..1	A quantitative score that indicates the strength of a Proposition's assessment in the direction indicated (i.e. how strongly supported or disputed the Proposition is believed to be). Depending on its implementation, a score may reflect how confident that agent is that the Proposition is true or false, or the strength of evidence they believe supports or disputes it. Instructions for how to interpret the meaning of a given score may be gleaned from the method or document referenced in 'specifiedBy' attribute.
`classification`	`MappableConcept` \| `iriReference`	0..1	A single term or phrase summarizing the result of direction and strength assessments of a Statement's Proposition, in terms of a classification of its subject.
`hasEvidence`	`Statement` \| `StudyResult` \| `DataItem` \| `iriReference`[] (unordered)	0..m	An individual piece of information that was evaluated as evidence in assessing the validity of the Proposition put forth by the Statement.
`hasEvidenceLines`	`EvidenceLine` \| `iriReference`[] (unordered)	0..m	Evidence lines grouping contributing submissions by review status priority tier. Each evidence line contains nested sub-statements (classification layer) or SCV references (aggregate contribution layer). Tiers are: practice guideline (PG), expert panel (EP), criteria provided (CP), and no criteria provided (NOCP).