Use Cases:
Hemoglobin Alleles - Below are just a few examples of hemoglobin alleles (including the most common, Hb S), there are many more less common alleles that have all been historically named, typically after the geographic origin of the first patient
Hb S allele http://www.ncbi.nlm.nih.gov/clinvar/variation/15333/
Hb C allele http://www.ncbi.nlm.nih.gov/clinvar/variation/15126/
Hb Zurich allele http://www.ncbi.nlm.nih.gov/clinvar/variation/15400/
References: http://www.ncbi.nlm.nih.gov/books/NBK1377/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579210/ http://globin.bx.psu.edu/