ClinvarScvStatement

Trial Use

This data class is at a trial use maturity level and may change in future releases. Maturity levels are described in the GKS Maturity Model.

A ClinVar SCV (submitted clinical variant) statement. Represents a single submitter's assertion about a variant-condition relationship, including their classification, direction, strength, method, and contributions.

Proposition Types

SCV statements support 12 proposition types across four categories:

Category	Proposition Types
Germline (10 types)	VariantPathogenicityProposition, ClinvarRiskFactorProposition, ClinvarProtectiveProposition, ClinvarDrugResponseProposition, ClinvarAffectsProposition, ClinvarAssociationProposition, ClinvarConfersSensitivityProposition, ClinvarOtherProposition, ClinvarNotProvidedProposition, ClinvarConflictingDataFromSubmitterProposition
Oncogenicity (1 type)	VariantOncogenicityProposition
Somatic Clinical Impact (1 type)	VariantClinicalSignificanceProposition — with evidence lines carrying VariantTherapeuticResponseProposition, VariantDiagnosticProposition, or VariantPrognosticProposition

See Propositions for the full type/code/predicate reference.

JSON Schema: ClinvarScvStatement

Some ClinvarScvStatement attributes are inherited from Statement, ClinvarScvStatementProperties.

Information Model

Field	Type	Limits	Description
id	string	0..1	The 'logical' identifier of the Entity in the system of record, e.g. a UUID. This 'id' is unique within a given system, but may or may not be globally unique outside the system. It is used within a system to reference an object from another.
name	string	0..1	A primary name for the entity.
description	string	0..1	A free-text description of the Entity.
aliases	string[] (unordered)	0..m	Alternative name(s) for the Entity.
extensions	Extension[] (unordered)	0..m	SCV-level extensions including submission metadata, review status, and condition mapping. See SCV Statements — Extensions for the complete list of extension names, value types, and custom type definitions.
specifiedBy	Method | iriReference	0..1	A specification that describes all or part of the process that led to creation of the Information Entity
contributions	Contribution[] (ordered)	0..m	Specific actions taken by an Agent toward the creation, modification, validation, or deprecation of an Information Entity.
reportedIn	Document | iriReference[] (unordered)	0..m	A document in which the the Information Entity is reported.
type	string	0..1	MUST be "Statement".
proposition	ClinvarProposition | iriReference	0..1	The proposition assessed by this SCV statement. Must be one of the GA4GH standard proposition types (pathogenicity, oncogenicity, clinical significance) or a ClinVar-specific proposition type (risk factor, protective, drug response, affects, association, confers sensitivity, other, not provided, conflicting data).
direction	string	0..1	A term indicating whether the Statement supports, disputes, or remains neutral w.r.t. the validity of the Proposition it evaluates.
strength	MappableConcept	0..1	A term used to report the strength of a Proposition's assessment in the direction indicated (i.e. how strongly supported or disputed the Proposition is believed to be). Implementers may choose to frame a strength assessment in terms of how confident an agent is that the Proposition is true or false, or in terms of the strength of all evidence they believe supports or disputes it.
score	number (draft)	0..1	A quantitative score that indicates the strength of a Proposition's assessment in the direction indicated (i.e. how strongly supported or disputed the Proposition is believed to be). Depending on its implementation, a score may reflect how confident that agent is that the Proposition is true or false, or the strength of evidence they believe supports or disputes it. Instructions for how to interpret the meaning of a given score may be gleaned from the method or document referenced in 'specifiedBy' attribute.
classification	MappableConcept	0..1	A single term or phrase summarizing the outcome of direction and strength assessments of a Statement's Proposition, in terms of a classification of its subject.
hasEvidenceLines	ClinvarSomaticEvidenceLine | EvidenceLine | iriReference[] (unordered)	0..m	Evidence lines for this SCV statement. For somatic clinical impact (SCI) statements, evidence lines carry target propositions (VariantTherapeuticResponseProposition, VariantDiagnosticProposition, or VariantPrognosticProposition) and an evidence outcome reflecting the AMP/ASCO/CAP tier. Germline and oncogenicity SCVs typically do not have evidence lines.