Classifications

Each statement type has a set list of classification values to which ClinVar normalizes historic or similar classification terms used by some submitters. These classification terms are mapped to the GKS VA statement class' direction and strength.

Germline Classification

The Germline Classification category groups 9 statement types.

#	Statement Type	Classification	Direction	Strength
G.01	Pathogenicity	Pathogenic	supports	definitive
		Pathogenic, low penetrance	supports	definitive
		Risk allele	supports	definitive
		Likely pathogenic	supports	likely
		Likely pathogenic, low penetrance	supports	likely
		Likely risk allele	supports	likely
		Pathogenic/Likely pathogenic	supports	\<null>
		Uncertain significance	neutral	\<null>
		Uncertain risk allele	neutral	\<null>
		conflicting data from submitters	neutral	\<null>
		Benign	disputes	definitive
		Likely benign	disputes	likely
		Benign/Likely benign	disputes	\<null>
G.02	Drug Response	drug response	supports	\<null>
G.03	Risk Factor	risk factor	supports	\<null>
G.04	Protective	protective	supports	\<null>
G.05	Affects	Affects	supports	\<null>
G.06	Association	association	supports	\<null>
		association not found	disputes	\<null>
G.07	Confers Sensitivity	confers sensitivity	supports	\<null>
G.08	Other	other	supports	\<null>
G.09	Not Provided	not provided	supports	\<null>

Oncogenicity Classification

The Oncogenicity Classification category groups only 1 statement type.

#	Statement Type	Classification	Direction	Strength
O.10	Oncogenicity	Oncogenic	supports	definitive
		Likely oncogenic	supports	likely
		Uncertain significance	neutral	\<null>
		Benign	disputes	definitive
		Likely benign	disputes	likely

Somatic Clinical Impact

The Somatic Clinical Impact category groups 1 primary statement type with up to 3 evidence statement types.

Clinical Significance (Primary)

#	Statement Type	Classification	Direction	Strength
S.11	Clinical Significance	Tier I - Strong	supports	strong
		Tier II - Potential	supports	potential
		Tier III - Unknown	neutral	\<null>
		Tier IV - Benign/Likely benign	disputes	\<null>

Evidence Statement Types

All Tier I and II Clinical Significance statements MUST have at least one of the following statement types as evidence. These sub-statement types are critical to Tier I and II clinical significance submissions in ClinVar.

#	Statement Type	Direction	Strength
S.12	Therapeutic Response	supports	strong or potential
S.13	Diagnostic	supports	strong or potential
S.14	Prognostic	supports	strong or potential